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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: We also explore the translational value of this well-annotated PDX panel in the development of co-clinical

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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Development and clinical trial of a novel bioactive bone cement

LEONG John, LI Zhaoyang, LU William

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 117-126 doi: 10.1007/s11684-008-0022-1

Abstract: In this paper, we review the and clinical evidence for the effectiveness of this bioactive bone cement

Keywords： bioactivity     effectiveness     strontium-containing hydroxyapatite     osseointegration     sufficient mechanical    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinicaltrial

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet (LCD) or exercise is more effective in metabolism improvement. Forty-five eligible subjects were randomly divided into an LCD group (n=22) and an exercise group (EX, n=23). The subjects either adopted LCD (carbohydrate intake<50 g/day) or performed moderate-to-vigorous exercise (≥30 min/day) for 3 weeks. After the interventions, LCD led to a larger weight loss than EX (−3.56±0.37 kg vs. −1.24±0.39 kg, P<0.001), as well as a larger reduction in fat mass (−2.10±0.18 kg vs. −1.25±0.24 kg, P=0.007) and waist circumference (−5.25±0.52 cm vs. −3.45±0.38 cm, P=0.008). Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance. Triglycerides decreased in both two groups, whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group. Various glycemic parameters, including serum glycated albumin, mean sensor glucose, coefficient of variability (CV), and largest amplitude of glycemic excursions, substantially declined in the LCD group. Only CV slightly decreased after exercise. This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance. Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean sensor glucose    

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multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinicaltrial

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 276-284 doi: 10.1007/s11684-021-0855-4

Abstract: In this trial (NCT01823315), 276 patients were analyzed.

Keywords： gestational trophoblastic neoplasia (GTN)     methotrexate (MTX)     dactinomycin (ACTD)    

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Immunosuppression and Liver Transplantation Review

Jan Lerut, Samuele Iesari

Engineering 2023, Volume 21, Issue 2,   Pages 175-187 doi: 10.1016/j.eng.2022.07.007

Abstract: The availability of different drugs has led to several, often industry-driven, heterogeneous clinicalBoth elements are critical to progress toward more prudent immunosuppression handling and favor clinical

Keywords： Liver transplantation     Immunosuppression     Rejection     Tolerance     Clinical trial    

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cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinicaltrial

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 231-239 doi: 10.1007/s11684-022-0939-9

Abstract: oligometastatic prostate cancer (OMPC), we conducted a 3 + 3 dose escalation, prospective, phase I/II, single-arm clinicaltrial (CHiCTR1900025743), in which long-term neoadjuvant androgen deprivation was adopted 1 month before

Keywords： neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract: Various types of NK cells are currently being applied in clinical trials, including autologous or allogeneicimmunotherapy, ways of enhancing the antitumor capacity of NK cells in vivo, and major challenges for clinical

Keywords： Natural killer cell     Immunotherapy     Cancer     Clinical trial     Chimeric antigen receptor    

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Syndrome and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-blind, Placebo-controlled, Pilot ClinicalTrial Article

Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen

Engineering 2021, Volume 7, Issue 3,   Pages 376-385 doi: 10.1016/j.eng.2020.06.026

Abstract: syndrome with diarrhea (IBS-D) is chronic intestinal dysfunction with diarrhea and other complicated clinicalThe study was a 12-week, randomized, double-blind, placebo-controlled, pilot clinical trial.The patients' clinical symptoms and quality of life were examined by the IBS symptom severityThese findings suggest that ingestion of L. plantarum CCFM8610 can significantly alleviate clinical

Keywords： Lactobacillus plantarum     Irritable bowel syndrome     Gut microbiota     Butyric acid     Clinical trial    

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The boron neutorn capture therapy (BNCT) status to go into the new era

Zhou Yongmao

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 4-13

Abstract: It includes the BNCT clinical positioning, the tumour recurrence exploring, the boron concentration quantifed

Keywords： neutron capture therapy     clinical trial     tumour recurrence     boron concentration detect     targeting boron    

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Trial design of arch bridge of composite box section with steel web-concrete flange

Jiangang WEI, Qingwei HUANG, Baochun CHEN,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3,   Pages 370-375 doi: 10.1007/s11709-010-0073-7

Abstract: Bridge (the longest concrete arch bridge in the world with a main span of 420 m) as a prototype, trialComparison of quantities and structural behaviors of the prototype concrete arch with the two trial designed

Keywords： steel webs     concrete     box arch     trial design     structural behaviors     finite element method    

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Balancing method without trial weights for rotor systems based on similitude scale model

Ruiduo YE, Liping WANG, Xiaojie HOU, Zhong LUO, Qingkai HAN

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4,   Pages 571-580 doi: 10.1007/s11465-018-0478-x

Abstract:

A balancing method without trial weights based on the dynamic similitude scale model was proposedThe balancing method without trial weights was proposed based on the similitude relationship of the influenceThe effect of the balancing method without trial weights was compared with that of the traditional influence

Keywords： rotor system     dynamic similitude     balancing     without trial weights     influence coefficient    

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Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 368-375 doi: 10.1007/s11684-014-0360-0

Abstract: chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomized controlled trialPatients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-PiA total of 136 patients≥65 years completed the study, with 63 patients comprising the trial groupsix-month treatment and the 12-month follow-up period, significant differences were observed between the trialNo differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%

Keywords： chronic obstructive pulmonary disease     older adult     clinical trial     Bu-Fei Jian-Pi granules     Bu-Fei Yi-Shen    

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oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinicaltrial

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 704-717 doi: 10.1007/s11684-021-0853-6

Abstract: We conducted a randomized, open-label, parallel-controlled, multicenter trial on the use of Shuanghuanglian

Keywords： COVID-19     SARS-CoV-2     Shuanghuanglian oral liquid     clinical trial    

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A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: This open label, randomized, controlled, non-inferiority trial was conducted at multiple sites in China

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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Title Author Date Type Operation

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical

Shuyang Sun,Zhiyuan Zhang

Journal Article

Development and clinical trial of a novel bioactive bone cement

LEONG John, LI Zhaoyang, LU William

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinicaltrial

Journal Article

multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinicaltrial

Journal Article

Immunosuppression and Liver Transplantation

Jan Lerut, Samuele Iesari

Journal Article

cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinicaltrial

Journal Article

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects

Yuan Hu, Zhigang Tian, Cai Zhang

Journal Article

Syndrome and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-blind, Placebo-controlled, Pilot ClinicalTrial

Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen

Journal Article

The boron neutorn capture therapy (BNCT) status to go into the new era

Zhou Yongmao

Journal Article

Trial design of arch bridge of composite box section with steel web-concrete flange

Jiangang WEI, Qingwei HUANG, Baochun CHEN,

Journal Article

Balancing method without trial weights for rotor systems based on similitude scale model

Ruiduo YE, Liping WANG, Xiaojie HOU, Zhong LUO, Qingkai HAN

Journal Article

Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Journal Article

oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinicaltrial

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Journal Article

Xiao Yonghong: Co-evolution of Clinical Highly Resistant and Highly Toxic Pathogens (2023-2-22)

10 Mar 2023

Conference Videos

A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Journal Article